ABSTRACT
The intraluminal middle cerebral artery occlusion (MCAO) model via a monofilament has been widely used for studies of acute focal cerebral ischemia and edema since its first description in 1986 by J. Koizumi et al. Besides the performer’s surgical skill, which can be improved by practice, the nature of the monofilament is the most important factor that affects the model’s outcome. The MCAO model induced by intraluminal filament implantation in mice is similar to the model in rats. In filament stroke model, the temperature did not increase in about 10% of the rats, whereas the body temperature increased in 90%; in the latter, 70% had a large infarct, and 20% had a smaller infarct with triphenyltetrazolium chloride stain. Temporal muscle necrosis has also been identified as a complication of the intraluminal filament model of MCAO. Postischemic spontaneous hyperthermia as a complication of occlusion of the middle cerebral artery with an intraluminal filament has been observed by some authors.
