ABSTRACT
Nowadays, systems biology is extending to cover almost all biological sciences, from cellular molecular biology (Westerhoff 2003), to whole organ and organism-level biomedical studies (Kitano 2007). An excellent review (Westerhoff and Palsson 2004, has been published on convergence between molecular biology and formal understanding (mathematical modelling) of biological systems as a whole. The authors claimed that the process started in the middle of the twentieth century when methods of molecular biology and theoretical generalization emerged. In our opinion, the history of systems biology (or knowledge-based interdisciplinary systems thinking) started much earlier.
