ABSTRACT

Sphingolipids are found in all eucaryotic cells, but are especially abundant in the plasma membrane and related cell membranes, such as endoplasmic reticulum, golgi membranes, and lysosomes. They are critical for the maintenance of membrane structure and play an important role in intracellular signaling pathways [1]. As receptors and ligands, they are involved in interactions between cells, and cells and matrix; they also serve as a binding site for toxins of bacterial and nonbacterial origin, hormones, and virus, among others [2,3].