ABSTRACT
This is both a new subject and chapter to the Second Edition of Pharmaceutical Process Scale-Up. Some elements of this chapter were described in the first edition of the Handbook of Pharmaceutical Granulation Technology, in the chapter titled Roller Compaction Technology, by the lead author in 1997 (1). A number of new equipment design features, research, roller compaction usage in the industry, and new technology advances have added to the best practices of roller compaction within the pharmaceutical unit operation in our industry. The interested reader will have to wait for a comprehensive book (in process at this time) to link numerous journal articles, chapters, and investigative works for technology completeness. This chapter serves the abbreviated purpose of defining roller compaction scale-up in the pharmaceutical industry.
