ABSTRACT
I. Introduction ..................................................................................................178 A. Glycosaminoglycan Chemical Structure ............................................180 B. Challenges of GAG Characterization ..................................................182
II. Techniques for the Depolymerization of Glycosaminoglycans ..................183 A. Chemical Techniques ..........................................................................183 B. Enzymatic Techniques..........................................................................185
III. Analytical Techniques for Glycosaminoglycan Characterization ..............188 A. Chromatography ..................................................................................188 B. Electrophoresis ....................................................................................189 C. Nuclear Magnetic Resonance ............................................................190 D. Mass Spectrometry ..............................................................................191
IV. Sequencing Glycosaminoglycans ................................................................192 V. Informatics-Based Approaches for Sequencing Glycosaminoglycans........194
