ABSTRACT
Abstract Palladium chlorides possessing phosphinous acid ligands (POPd, POPd1 and POPd2) were found to be remarkably active and efficient catalysts in the presence of bases for a variety of cross-coupling reactions of aryl chlorides with arylboronic acids, olefins, amines, and thiols. ¹H and ³¹P NMR studies argue that these phosphinous acid ligands in the complexes can be deprotonated to yield electron-rich anionic species, which is anticipated to accelerate the rate determining oxidative addition of aryl chlorides in the catalytic cycle. Herein, we report the first examples of these isolated air-stable palladium complexes served as efficient catalyst precursors for C-C, C-N, and C-S bond-forming reactions of aryl chlorides.
