ABSTRACT
A. S. Kotnis,* K. Zhu, B. L. Lotz, K. J. Natalie, J. H. Simpson, D. Kacusr, D. Thurston, J. S. Prasad, S. Mathew, and A. K. Singh
Process Research and Development, Bristol-Myers Squibb Pharmaceuticals,
New Brunswick, NJ 08903-0191
atul.kotnis@bms.com
Abstract The focus of this paper is on the preparation of biaryl moieties which are commonly present in a wide variety of pharmaceutically active compounds. Two different and practical approaches to synthesize the biaryl substructure will be discussed. Introduction Nature has an abundance of biologically interesting and pharmaceutically active natural products possessing the biaryl moiety. Synthetic chemists have thus devised a number of different methods to assemble the biaryl functionality.
