ABSTRACT
Metrics for HTS ............................................................................. 110 5.2.3 The Cost of High-Throughput Screening ................................. 112 5.2.4 High-Throughput Screening Successes to Date ....................... 113
5.2.4.1 Direct Impact of HTS on Clinical Trials and Beyond........................................................... 114
5.2.4.2 Indirect Benefits of HTS ................................................ 115 5.3 Requirements for HTS............................................................................... 116
5.3.1 Compound Collections and Infrastructure............................... 116 5.3.1.1 Library Access and Design ........................................... 116 5.3.1.2 Library Composition and Formats .............................. 117
5.3.2 Cell Production Requirements .................................................... 118 5.3.3 HTS Infrastructure ........................................................................ 119 5.3.4 Informatics Architecture...............................................................121
