ABSTRACT
Traditional MIP preparation involves polymerization in bulk followed by a grinding and sieving process to obtain particles smaller than 30 mm dimension. While this technique has shown much success, it also has several recognized limitations. The tedious grinding and sieving process commonly yields nonuniform particles in shape and size, which causes numerous problems such as limitations in chromatographic e⁄ciency. Furthermore, the act of sieving may result in material loss as particles too small are discarded.
