ABSTRACT

DNA microarrays are increasingly being used to study the molecular basis of complex disease traits, such as diabetes and coronary artery disease, as well as fundamental biological processes, such as lipid metabolism.[1-4] For example, microarrays can be used to investigate dietary effects on mRNA levels in cells or tissues[5-7] or effects of gene knockout.[8,9] Knowledge gained from such experiments advances understanding of molecular mechanisms and pathways involved in both normal and pathologic physiology, which can lead to improvements in food functionality, health, and disease treatment and prevention.