ABSTRACT
Lipids are components of most foods. Besides their principal dietary role of delivering energy to the body, dietary lipids are involved in normal and aberrant mitogenic processes, and have been linked to the development and progression of colon, liver, and mammary carcinogenesis. Lipids influence multiple signaling pathways involved in disease progression, most of which are difficult to study with a single-gene/protein/biomarker approach. These disease states are inherently multiparametric. Therefore, the highly parallel measurement approach central to nutrigenomics is needed to further scientific understanding. These 296tools have been largely unavailable in the past; thus the mechanisms by which lipids influence cancer have been mostly unknown.
