ABSTRACT
Type 2 diabetes is a polygenic disease affecting over 100 million people worldwide. Affected patients manifest insulin resistance, hyperinsulinemia, and hyperglycemia.[1] Insulin resistance in peripheral tissues including liver, fat, and skeletal muscle characterizes type 2 diabetes and is also associated with obesity, hypertriglyceridemia, and hypertension. The molecular mechanism underlying insulin resistance is not well understood but appears to involve a defect in the postinsulin receptor (IR) signal transduction pathway.[2]
