ABSTRACT
Since aqueous solubility of sparingly or insoluble substances had been found to remarkably increase with addition of soap
as the third component, systematic studies were conducted on this phenomenon using surfactants and led to the establishment of the concept of solubilization. This term solubilization now has a general definition: ‘‘formation of a thermodynamically stable isotropic solution of a substance normally insoluble or slightly soluble in a given solvent with the aid of one or more amphiphilic components.’’ Many solubilizationdependent applications are found in diverse fields of industry, e.g., dissolution of water-insoluble drugs into aqueous solution and their delivery to various parts of the body, preparation of agricultural solutions, production of cosmetics and toiletries, food processing, etc. [1]. Solubilization also plays a very important role in biological processes as found in, for example, digestion and absorption of lipids by bile acids/ salts.
