ABSTRACT

Severe obstructive pulmonary disease, severe heart failure, second-or thirddegree heart block, severe sinus node disease, asthma or active allergic rhinitis

Diltiazem, Verapamil

BP, HR, angina symptoms, signs/symptoms of heart failure

Hypotension, bradycardia, dizziness, headache, flushing, edema, skin reactions, exacerbation of preexisting heart failure, constipation, AV block

Second-or thirddegree heart block, severe heart failure, severe sinus node disease, acute MI and pulmonary congestion (diltiazem), hypotension (SBP <90 mm Hg), atrial fibrillation with an accessory AV pathway (verapamil)

Amlodipine, Felodipine, Isradipine, Nicardipine, Nifedipine, Nimodipine, Nisoldipine

BP, HR, angina symptoms, signs of peripheral edema

Dizziness, hypotension, flushing, headache, peripheral edema, tachycardia

Symptomatic hypotension, advanced aortic stenosis (nicardipine)

Drug/Drug Class

Monitoring Parameters

Common Adverse Effects Contraindications

Bepridil BP, HR, angina symptoms, WBC count, QT interval, ECG for ventricular ectopy, serum potassium

Shortness of breath, dizziness, nervousness, tremor, palpitations, nausea, asthenia, diarrhea, headache, QT prolongation, agranulocytosis (rare)

History of ventricular arrhythmias, uncompensated cardiac insufficiency, congenital QT prolongation, use with other drugs that prolong the QT interval, sick sinus syndrome, 2° or 3° heart block, hypotension (SBP <90 mmHg

Nitrates BP, HR, anginal frequency, headache, dizziness

Dizziness, headache, flushing, weakness, nausea/vomiting, palpitations, tachycardia, postural hypotension, contact dermatitis with transdermal patches

Severe anemia, severe hypotension or uncompensated hypovolemia, increased intracranial pressure, use of sildenafil, closed angle glaucoma, constrictive pericarditis, cardiac tamponade

BP = blood pressue, HR = heart rate, WBC = white blood cell, ECG = electrocardiogram, CNS = central nervous system, AV = atrioventricular, MI = myocardial infarction, SBP = systolic blood pressure.