ABSTRACT
Alcohol consumption of more than 40 g alcohol per day in women and more than 60 g alcohol per day in men significantly increases the risk for developing alcoholic liver disease (ALD). The pathogenesis of ALD is multifactorial. When alcohol is metabolized, oxygen is consumed, centrilobular hypoxia develops, and proinflammatory cytokines and toxic metabolites are produced. Additionally, cofactors such as gender, genetic predisposition, and nutrition play important roles in initiating and promoting ALD.
