ABSTRACT
The aim of this ongoing study is to produce a tracer which can assist in diagnosing the Alzheimer’s diseases in vivo by binding specifically to the cerebral Aβ-amyloid. To this end a D-amino acid peptide has been selected (and published) that specifically binds to human Aβ-amyloid in tissue sections. The question in this report was whether this D-peptide would also bind specifically to Aβ-amyloid in tissue sections of aged and demented dogs due to Aβ-amyloid deposits found mainly in leptomeningeal vessels. Here we show specific binding of this D-peptide to canine Aβ-amyloid on four demented dogs while cerebral tissue of two non-demented dogs lacking amyloid did not bind this peptide.
