ABSTRACT
Data is accumulating to suggest that a certain amyloidosis including AA and mouse AApoAII amyloidosis are transmissible. It is postulated that invasion of preexisted amyloid seed into the hosts plays a critical role in the transmission. The degree of denaturation / degradation of amyloid fibrils were evaluated by thioflavine T fluorescence assay and electron microscopy of aliquot. Data is accumulating to suggest that a certain amyloidosis including AA and mouse AApoAII amyloidosis are transmissible. It is postulated that invasion of preexisted amyloid seed into the hosts plays a critical role in the transmission. In order to search for a measure to eliminate or attenuate amyloid-seeding activity, we evaluated inhibitory effects of several treatments and medical reagents on amyloid fibril in the mouse AApoAII transmission model system. Generally AApoAII amyloid deposition was decreased in mice administered with denatured fibrils as compared with that in mice administered native fibrils.
