ABSTRACT
Myocardial involvement results in severe dysfunction and is the leading cause of death in patients with amyloidosis. NT-proBNP concentration at presentation was measured with an electrochemiluminescence sandwich immunoassay on an Elecsys System 2010 in 17 patients with ATTR amyloidosis, diagnosed at the Pavia amyloid center and at the Porto Amyloid Unit, and in 17 Amyloidosis (AL) patients, referred to the Pavia amyloid centre. Amyloidogenic light-chain with cardiac tropism generate more severe myocardial dysfunction than transthyretin amyloidogenic variants despite comparable wall thickening at echocardiography. Serum N-terminal fragment of natriuretic peptide type B (NT-proBNP) is a sensitive marker of amyloid cardiomyopathy and the most powerful prognostic determinant in AL.
