ABSTRACT
The presence of chronic inflammation in the body results in the development of AA amyloidosis. Inflammation and mild or moderate forms of renal insufficiency are associated with increased oxidative and carbonyl stresses. This chapter aims to test the hypothesis if the patients with AA amyloidosis and mild or moderate renal insufficiency do produce an increase of carbonyl/oxidative stress end products compared with pts suffering from rheumatoid arthritis without signs of AA amyloidosis and healthy controls. It investigates a new parameter of microinflammation - pregnancy associated plasma protein A (PAPP-A), which has a close relation to oxidative stress and is a new parameter of acute coronary syndrome. The chapter also investigates advanced glycation end products (AGEs), advanced oxidation protein products and PAPP-A as the parameters od carbonyl/oxidative stress, serum amyloid A, CRP and orosomucoid as the parameters of inflammation. Determination of AGEs was based on spectrofluorimetric detection according to Henle and Munch in our modification.
