ABSTRACT
Software for assisting patients with diabetes can be clustered into three groups: software for daily logs of food intake and computation of the insulin dose to be administered based on food consumption; software for interpreting data collected from a subject; and simulation software for illustrating dynamic variations in blood-glucose concentration. This chapter describes web-based simulation of the dynamics of the glucose—insulin system and presents the GLUCOSIM simulator, based on a compartmental mathematical model. GLUCOSIM can illustrate the effects of body weight, food, insulin dose, type and delivery time, and moderate exercise. Modeling glucose-insulin interaction in the human body requires an understanding of the physiological and metabolic processes that influence the variations observed over time in blood-glucose concentration. The detailed mathematical model developed for a patient with type 1 diabetes is revised to simulate glucose—insulin interaction in an average healthy person.
