ABSTRACT
This part introduction presents an overview of the key concepts discussed in the subsequent chapters. The part begins with an elegant overview of how oxidative stress that is associated with nutrient stimulation of insulin secretion paradoxically affects the regulation of insulin secretion, a situation that could potentially contribute to β-cell failure in diabetes. This is followed by a clinical illustration of how oxidative stress is associated with type 1 diabetes and its neuropathic complications. Mortality in type 2 diabetes is largely attributed to the cardiovascular complication of the disease, which has a strong link with oxidative stress that plays a significant role in other vascular complications of diabetes. A detailed discussion of the pathogenesis of vascular disease, as attributable to oxidative stress, is provided along with strategies for the management of these complications. The part discusses two other major complications of diabetes associated with oxidative stress, neuropathy and nephropathy.
