ABSTRACT

Caffeine ................................................................................................... 87 Pharmacokinetics.................................................................................... 88 Pharmacodynamics ................................................................................ 88 Age-Related Pharmacodynamic Changes ............................................. 89 Sleep ........................................................................................................ 90 Age-Related Changes in Sleep Pattern.................................................. 90 Caffeine and Insomnia ........................................................................... 91 Conclusion .............................................................................................. 94 References ............................................................................................... 94

Caffeine is the world’s most ubiquitously used drug, with 96% of an American population having ever used and 83% at present using, one or more caffeinated beverages weekly.