ABSTRACT
In adult animals and humans dietary fat intake is widely recognized to be associated with gain of fat body mass. During development, evidence also exists that a fatty diet is associated with fat body mass and obesity. The enhanced neutral lipid accumulation is consistent with the increased activities of lipoprotein lipase, fatty acid synthase, and malic enzyme in COD pups as compared to superoxide dismutase genes pups. The transcriptional effect of exogenous fatty acids (FA) was observed in culture in glucose-supplemented preadipose cells as well as in glucose-free adipose cells, that is under conditions where endogenous fatty acid synthesis remained low. Long-chain FA (LCFA) were able to activate within a few hours the aP2 gene but also the gene encoding for the acyl-CoA synthase-1. The intensity and duration of the flux of dietary LCFA entering adipose tissue, proportionate to the amount of ingested fat, is assumed to alter transiently the intracellular concentrations of LCFA and/or their metabolites within the nucleus.
