Novel Cerebellar Function: Neurosteroids in the Purkinje Neuron and their Genomic and Nongenomic Actions

I. Introduction................................................................................. 101 II. Neurosteroids in Vertebrates ..................................................... 102

III. Neurosteroidogenic Enzymes .................................................... 104 IV. Neurosteroidogenesis in Cerebellar Purkinje Neurons ........... 105 V. Possible Actions of Neurosteroids Produced in

Purkinje Neurons ........................................................................ 107 A. Nongenomic Actions as a Novel Modulator of

Neuron-Neuron Communications........................................ 107 B. Genomic Actions as a Classical Regulator of Gene

Expressions ............................................................................ 108 VI. Other Evidence for Neurosteroid Actions ................................ 110

VII. Conclusions ................................................................................. 110 VIII. Acknowledgments .......................................................................111 References ..............................................................................................111