ABSTRACT

Mitsuhiro Kawata, Mayumi Nishi, Ken-ichi Matsuda, Hiroshi Ogawa, Ikuo Ochiai, and Maki Yoshida

CONTENTS

I. Introduction................................................................................. 273 II. Localization of Corticosteroid Receptors in the Brain ............ 274

III. Subcellular Localization of Corticosteroid Receptors.............. 275 IV. Localization of Sex Steroid Hormone Receptors

in the Brain.................................................................................. 277 V. Subcellular Localization of Sex Steroid Hormone

Receptors ..................................................................................... 279 VI. Localization of Coactivators in the Brain ................................. 280

VII. Subcellular Localization of Nuclear Receptor Coactivators and Dynamic Intracellular Trafficking of Steroid Hormone Receptors .................................................. 281

References ............................................................................................. 282

The brain is a target organ for circulating steroid hormones secreted from peripheral endocrine tissues. Steroid hormones regulate many important functions not only during development, but also into adulthood. Due to their chemical property of lipid solubility, steroid hormones cross the blood-brain barrier and function on neuronal cells through their receptors.