ABSTRACT
I. Introduction................................................................................... 45 II. Molecular Mechanisms of Thyroid Hormone Action:
A General Overview ..................................................................... 46 III. Rodent Cerebellum as a Model System to Study the
Effects of TH on Neuronal Development ................................... 47 IV. Current Progress in Our Understanding of the Molecular
Mechanisms of Thyroid Hormone Action in Cerebellar Development ................................................................................. 47 A. A Possible Involvement of ROR
α
, an Orphan Nuclear Receptor, in TH-Mediated Brain Development .................... 49
B. Role of Neurotrophins in Cerebellar Development.............. 50 C. Other Potential Critical Target Genes of Thyroid
Hormone and Modulation Factors of Thyroid Hormone Receptor-Mediated Transcription.......................... 51
V. Conclusions ................................................................................... 52 References ............................................................................................... 54
The important influence of thyroid hormone (L-triiodothyronine, T3; L-tetraiodothyronine, T4; TH) on the growth and differentiation of many organs including the central nervous system is well known.
