Amphiphilic monolayers are known as the useful models for study mechanisms of different biophysical and biochemical phenomena in living cells. The main attention will be devoted to evaluation of monolayer surface pressure. To analyze the dependence of the electrostatic component of surface pressure upon the kind of monolayer substance, ionic composition, and subphase concentration, some approaches described in the literature were offered. Electrostatic component of surface pressure in monolayers with dipole distribution of charges is usually determined with regard to the energies of rotary and oscillatory movements of amphiphilic molecules. The effects concerned with discrete structure of monolayers were analyzed in works of Bell, Levine, and Pethica. The certain contribution to the generation of electrostatic component of surface pressure also can be made by effects caused by local curvatures of subphase surface in the location sites of separate monolayer molecules.