ABSTRACT
Electrically or chemically induced seizure models represent models of seizure states rather than epilepsy, a chronic disorder. Animals with chronically recurring spontaneous seizures represent ideal models for human epilepsy, but the major drawback of these models is that naturally occurring seizures cannot be elicited by an investigator. The first clinical study on epileptic patients was performed with compound BF 2.649 on pharmacoresistant epilepsy and on photosensitive seizures. The potential of histamine H3 receptor ligands in epileptic seizures highlights an important role of histaminergic mechanisms in the pathophysiology of epilepsy and thus identifies histamine as yet another novel molecular target that can be exploited for antiepileptic drug development. Various drugs that modulate brain histamine affect experimental seizures. Although a large amount of data point toward a role of drugs modulating brain histamine on seizures, there are relatively fewer studies examining the role of drugs modulating seizures on brain histamine.
