Statistical Approaches to Gene Expression Microarray Data Preprocessing

Over the past decade, gene expression microarray the technology has revolutionized the way we measure the level of gene transcripts in biological organisms. Traditionally, researchers used northern blotting or polymerase chain reaction (PCR) to measure the expression level of a few genes in a single experiment. Now, the expression levels of thousands of genes can be measured in one single microarray hybridization. Researchers can view the expression profiles of genes on a whole genome scale.