ABSTRACT
In the past decade, high-throughput sequence technology has made 700 genomes fully sequenced as of October 2008 (https://www.ncbi.nlm.nih.gov/ genomes/lproks.cgi). In order to keep up with the sequencing pace, researchers have annotated coding genes of the genomic data and predicted gene function. This level of genome annotation is known as one-dimensional genome annotation [1]. The next grand challenge is to understand how gene products (either RNA genes or proteins) interact with each other and govern the
T&F Cat # C6847 Chapter: 16 page: 377 date: August 5, 2009
T&F Cat # C6847 Chapter: 16 page: 378 date: August 5, 2009
transcriptional rates of genes in the network. Such an annotation, a regulatory network annotation, is also known as two-dimensional genome annotation [1].
