ABSTRACT
Technologies such as combinatorial chemistry, high throughput screening (HTS), and high throughput genomics/proteomics have increased the speed at which new chemicals are made and tested within various biological systems. This has led to a significant increase in the amount of chemicals and related biological data available to researchers. The associated biological data includes biological activity data, toxicity, and differential gene/protein expression on cellular response to compound treatment. The ability to data mine these large chemical databases alongside the biological information is critical to the discovery of new therapeutic agents and to providing insight into disease mechanisms. Table 26.1 illustrates the availability of a number of large chemical databases in the public domain.
