ABSTRACT
Morphology at Intravenous Particle Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 774 29.5 Local Laser Hyperthermia and Thermolysis of Normal Tissues, Transplanted and
Spontaneous Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 781 29.6 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 790
Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 791 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 792
We describe an application of plasmonic silica/gold nanoshells to produce a controllable local laser hyperthermia or thermolysis of tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom and laboratory rats. Temperature distributions on the animal skin surface at hypodermic and intramuscular injection of gold nanoparticle suspensions and affected by the laser radiation are measured in vivo with a thermal imaging system. It is shown that the temperature in the volume region of nanoparticle location can substantially exceed the surface temperature recorded by the thermal imaging system. The results of temperature measurements are compared with tissue histology results. Nanoshell-based photothermal therapy in several animal models of human tumors gave highly promising results; the dosage information, thermal response, and tumor outcomes for these experiments are presented.
