ABSTRACT
The success of high throughput screening (HTS) is based simply on the efficient retrieval, reduction and analysis of massive amounts of information. Such information is derived from the bioevaluation of a large number of compounds in a large number of assays with the rationale that this statistical, “shotgun” approach can provide insight into the molecular bioreactivity of a new receptor or enzymatic site. With sufficient structural diversity of the test substances and the receptivity of the target to small molecule interference, the system works.
