ABSTRACT
The HTS laboratory can be viewed as an information hub for the drug discovery process. Gene products are identified and submitted for assay development. The assays are optimized for automation and submitted for screening. Once active compounds are discovered they are investigated by medicinal chemists and targeted for analog synthesis. The analogs are then screened to complete the feedback loop for the chemists. In many cases there is an active information pipeline between the HTS lab and structural biochemists utilizing molecular design software and chemical structure databases. The specific responsibilities of a competent data management system include some or all of functions outlined below.
