ABSTRACT
The decade of the ‘90’s has been a turbulent one for the pharmaceutical industry; the only constant has proven to be change. Chemistry as practiced within the pharmaceutical industry has changed at least as much as business strategy or any of the other key disciplines that contribute to new drug development. Discovery chemists have incorporated combinatorial chemistry, automated synthesis and virtual screening into their search for new drug candidates. These changes have been undertaken to decrease the time required for the discovery phase of drug development, to increase the number of new drug candidates and to decrease the resources (including amount of compound used) applied during the discovery phase.
