ABSTRACT

H.U. Blaser1, R. Gamboni2, B. Pugin1, G. Rihs1, G. Sedelmeier2, B. Schaub2, E. Schmidt2, B. Schmitz2, F. Spindler1 and Hj. Wetter2

Scientific Services a nd2Chemical and Analytical Development Pharma, Novartis AG, CH-4002 Basel, Switzerland

Keywords: Chiral building block, enantioselective hydrogenation, f^-epichlorohydrin,

(7^-levoprotiline, ligand synthesis, process evaluation.