ABSTRACT
Among the major challenges in Alzheimer’s disease (AD) research is the generation of authentic animal models which reflect important aspects of the disease pathogenesis. Two primary motives account for the urgent need for such models. They can be excellent research tools when analyzing the molecular mechanisms involved in the development of AD. Without them studies in organisms are largely restricted to post mortem material from the brains of AD patients. Furthermore, testing of compounds in a predictive model prior to clinical trials is highly desirable for ethical reasons. Moreover, clinical studies in AD are extremely expensive due to the large groups of patients required as well as their long duration.
