ABSTRACT
Mammalian Bone Is Continuously Remodeled Resorption of old bone by osteoclasts followed by formation of new bone by osteoblasts is a
central event in bone physiology. These two closely coupled events are crucial for keeping anatomical and structural integrity of the skeleton.18 Bone remodeling runs cyclically with osteoclasts adhering to bone to remove it by acidification and proteolytic digestion. Then osteoblasts invade the resorption site and form new bone by secreting and mineralizing osteoid. After this, another type of cells, the lining cells, cover the area to restart the cycle again.18
