ABSTRACT
Oxidative stress participates in the complex process of carcinogenesis. Any carcinogenmay initiate the process of cancer development by generating free radicals. Numerousindicators of oxidative damage are enhanced in result of this carcinogenic action. Melatonin (N-acetyl-5-methoxytryptamine), an antioxidant and free radical scavenger, can potentially protect against oxidative damage and cancer initiation. Indeed, in numerous studies, examining several parameters of oxidative damage and using a number in vitro and in vivo models, this indoleamine has been shown to protect DNA and cellular membranes from carcinogen-induced oxidative abuse. The protection, provided by melatonin against cellular damage, due to carcinogens, makes it a potential therapeutic supplement in conditions of increased cancer risk.
