ABSTRACT
Gemifloxacin, although technically a 6-fluoronaphthyridone, is usually considered among the closely related fluoroquinolone class of antimicrobial agents. Originally designated LB20304 (later also termed SB-265805), gemifloxacin was synthesized by LG Chemical Ltd. in Korea (Oh et al., 1996). The chemical formula of gemifloxacin is (R,S)-7-[(4Z)-3- (aminomethyl)-4-(methox-yimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. In 2003, the US Food and Drug Administration (FDA) approved the mesylate salt of gemifloxacin (Factive; C18H20FN5O4 · CH4O3S, molecular weight 485.49) as an antibacterial agent for oral administration in the form of tablets, each containing the equivalent of 320 mg of gemifloxacin (Merus Labs International, 2013). The chemical structure of gemifloxacin mesylate is shown in Figure 106.1. Chemical structure of gemifloxacin mesylate. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig106_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
