ABSTRACT
Avarofloxacin and zabofloxacin are conventional fluoroquinolones with a fluorine atom inserted at position 6 in the quinolone ring, while nemonoxacin is a non-fluorinated quinolone (Karpiuk and Tyski, 2013). It has been suggested but not proven that removal of the fluorine atom may improve the adverse event profile of these agents (Barry et al., 2001). All three agents are under various stages of clinical evaluation, with their mechanism of activity similar to other agents in this class (Jacoby, 2005; Redgrave et al., 2014; Van Bambeke, 2014; see Chapter 101, Ciprofloxacin).
