ABSTRACT
Fleroxacin (Ro 23-6240, AM 833) is different from other fluoroquinolones such as ciprofloxacin or ofloxacin, since it is a trifluorinated quinolone, having three fluorine atoms, rather than one, attached to the quinolone ring system. It is a 6,8-difluoro-1-(2-fluorethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolonine carboxylic acid (Figure 113.1). A major advantage of fleroxacin is its long half-life, allowing once daily dosing. However, the extra fluorine atoms have led to a higher rate of dose-related adverse side effects, such as photosensitivity, compared to other fluoroquinolones (Domagala, 1994), leading to the withdrawal of the drug in many countries. Structure of fleroxacin. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig113_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
