ABSTRACT
Lomefloxacin is a second generation difluoroquinolone and has the chemical name 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid (see Figure 116.1). Relative to norfloxacin, it has a similar spectrum of activity but better tissue penetration and, because of a longer half-life, can be given once daily (see Chapter 102, Norfloxacin). Lomefloxacin appears to be effective in the treatment of urinary tract and nonpneumococcal respiratory tract infections. With the availability of newer fluoroquinolones that have broader spectra of activity, similar once daily dosing, and lower incidence of phototoxicity, its use is limited (Shin et al., 2014) although it remains available in parts of Asia and Europe. Similar to enoxacin (see Chapter 112, Enoxacin), environmental contamination with lomefloxacin has been identified in some regions (but not others), presumably due to its use in food production, especially in swine (Xiao et al., 2008; Adachi et al., 2013; Herrick et al., 2014; Lei et al., 2015; Xu et al., 2015). Chemical structure of lomefloxacin. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig116_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
