ABSTRACT
Nalidixic acid (1ethyl-l,4-dihydro-7-methyl-4-oxo-1, 8-naphthyridine-3-carboxylic acid) is one of a series of 1,8-naphthyridine derivatives that were first synthesized by Lesher et al. (1962) from a distillate during chloroquine synthesis (Neu, 1987; see Figure 117.1). Nalidixic acid was introduced into clinical use in 1964 and has a significant historical role as the prototype of the quinolone group of drugs. Chemical structure of nalidixic acid. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig117_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
