ABSTRACT
Pefloxacin is a second generation fluoroquinolone that has the chemical name l-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(4-methyl-1-piperazinyl)-quinoline-3-carboxylic acid (see Figure 118.1). Overall, the antibacterial spectrum of pefloxacin is similar to that of norfloxacin and enoxacin (see Chapter 102, Norfloxacin, and Chapter 112, Enoxacin), but is less than that of ciprofloxacin (see Chapter 101, Ciprofloxacin) (Auckenthaler et al., 1986; Clarke et al., 1985; King and Phillips, 1986; Ligtvoet and Wickerhoff-Minoggio, 1985; Van Caekenberghe and Pattyn, 1984). Although pefloxacin has little clinical advantage over these other fluoroquinolones, its good penetration of the central nervous system is notable; however, there are only limited clinical data available to support its use for treatment of infections of the central nervous system. Pefloxacin is only available in some European and Asian countries. Chemical structure of pefloxacin mesylate. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig118_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
