ABSTRACT
Rufloxacin, or 9-fluoro-10-(-methyl)-piperazinyl-7-oxo-2,3-dihydro-7H-pyrido-(1,2,3, de)-(1,4)-benzothiazine-6-carboxylic acid, is an older generation fluoroquinolone developed in 1989 with the chemical structure shown in Figure 119.1. Its spectrum of activity is less than or similar to that of ciprofloxacin and norfloxacin, although it has a longer half-life. Because of concerns about inferior activity, as well as higher rates of phototoxicity and neuropsychiatric adverse effects, rufloxacin has been discontinued throughout most regions of the world except for Italy and China. Chemical structure of rufloxacin. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig119_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
