Amphotericin B Deoxycholate

Amphotericin B deoxycholate (AMB, Fungizone, Bristol-Myers Squibb, New York, NY) is a polyene antibiotic with primarily antifungal and antiparasitic activity. Its molecular formula is C₄₇H₇₃NO₁₇ with molecular weight of 924.08 daltons. It is most often used in the treatment of pathogenic yeasts and molds, as well as the protozoan parasite Leishmania spp. In common with other polyenes, AMB is composed of a ring of carbon atoms with a series of conjugated carbon–carbon double bonds on one side and hydroxyl groups on the other side (Hamilton-Miller, 1973). It has a mycosamine ring bonded to the molecule. The structure of amphotericin B is shown in Figure 141.1. Figure 141.1 Chemical structure of amphotericin B. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig141_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>