ABSTRACT
Amphotericin B lipid complex (ABLC) consists of amphotericin B (AmB) complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio and forms large ribbon-like structures of 1.6–11 µm in its greatest diameter (Figure 143.1). ABLC is a sterile, pyrogen-free suspension for intravenous infusion. The two phospholipids l-α-dimyristoylphosphatidylcholine (DMPC) and l-α-dimyristoylphosphatidylglycerol (DMPG) are present in a 7:3 molar ratio. ABLC is yellow and opaque in appearance, with a pH of 5–7 (Abelcet Summary of Product Characteristics, Sigma-Tau Pharmaceuticals, 2015). (a) Chemical structure of amphotericin B. (b) Schematic of the molecular composition of amphotericin B lipid complex (ABLC). ABLC is composed of dimyristoyl-phosphatidylcholin/dimyristoyl-phospatidylglycerol (DMPC/DMPG) in a 7:3 molar ratio complexed with amphotericin B and the associated complexes form large ribbon-like structures. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig143_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/> (Adapted with permission from Groll and Walsh, 2009, and Janoff et al., 1993.)
