ABSTRACT
Natamycin is a tetrene polyene antifungal agent, isolated from Streptomyces natalensis (Struyk et al., 1958). It is a highly toxic polyene and is unsuitable for systemic treatment. It has limited treatment applications and is used mainly for fungal keratitis caused by Fusarium spp. or Acremonium spp. and other molds; it is also used as an antimicrobial food additive to protect food from mold and yeast growth. It has not been extensively evaluated either in vitro or in vivo. The chemical structure of natamycin is shown in Figure 145.1. Chemical structure of natamycin. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig145_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
