ABSTRACT
Voriconazole (Vfend, UK-109,496) is a synthetic triazole derivative with potent broad-spectrum activity. Voriconazole has the chemical name (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol with the empirical formula C16H14F3N5O and molecular weight of 349.3. Its structure is similar to fluconazole, but one triazole ring is replaced with a fluorinated pyrimidine and an alpha-methyl group is added to the propanol backbone. The chemical structure is shown in Figure 156.1. Chemical structure of voriconazole. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig156_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
